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Itraconazole (ITZ) has been the mainstay of oral antifungal treatment for the current epidemic of recalcitrant dermatophytosis (RD) in India. Recently, a newer formulation of ITZ, super bioavailable itraconazole (SUBA-ITZ), is made available in the market by many pharmaceutical companies. It is important for dermatologists to understand the pharmacokinetic properties of SUBA-ITZ vis-a-vis conventional pellet formulation to use it effectively and safely. Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) has established a special interest group for recalcitrant dermatophytosis (SIG-RD) to strengthen research, continuing medical education, and industry collaboration on the subject. This position statement on SUBA-ITZ by SIG-RD is an attempt to address current pieces of evidence and the position of this new formulation in the management of RD. [ABSTRACT FROM AUTHOR]

Recycled aggregate refers to crushed concrete, mortar, bricks, or asphalt derived from construction debris and repurposed in other building projects. It is obtained by crushing demolished waste to reclaim the aggregate. Over the past few decades, the abundance of Construction and Demolition Waste (C&DW) has increased significantly, leading the concrete industry to incorporate it, thereby reducing the cost of aggregates. The use of C&D waste in construction not only decreases carbon emissions but also facilitates the expansion of the concrete industry without causing harm to the environment. The objective of this study is to analyze the mechanical properties such as compressive strength, splitting tensile strength, flexural strength, and durability properties such as resistance to chloride, carbonation, freeze, and thaw of concrete utilizing recycled aggregate. It is observed that the mechanical and durability behavior of Recycled Aggregate Concrete (RAC) is inferior to that of standard concrete. However, by employing different admixtures and mixing approaches, the desired properties can be achieved. Furthermore, the study indicates that the improvement of mineral admixtures contributes more to enhancing the performance of recycled aggregate than it does to the characteristics of natural aggregate. [ABSTRACT FROM AUTHOR]

Pemphigus variants are treated with immunosuppressives and immunomodulators, but often, clinical remission is challenging. We report a case of pemphigus vulgaris (PV) with involvement of skin, oral mucosa, and esophagus, which failed to respond to commonly used drugs but showed a good response to lenalidomide. [ABSTRACT FROM AUTHOR]

Preterm babies have immature immunity and skin barrier functions. To cope up with these, many times they are kept under observation in neonatal care unit (NICU) for months until they attain their normal physiological age, weight, and immune functions along with other vital capacities. We are reporting such a curious case of 1-month-old preterm child who presented with the sequence of blackish blue to yellowish discoloration of thumb nails in both the hands. [ABSTRACT FROM AUTHOR]

Plica neuropathica is a rare scalp condition, which is manifested as a compact mass of scalp hair. Previously, it has been found to be associated with a variety of dermatological disorders. We report a case of 15-year-old female presenting with alopecia areata associated with plica neuropathica. [ABSTRACT FROM AUTHOR]

Itraconazole (ITZ) has been the mainstay of oral antifungal treatment for the current epidemic of recalcitrant dermatophytosis (RD) in India. Recently, a newer formulation of ITZ, super bioavailable itraconazole (SUBA-ITZ), is made available in the market by many pharmaceutical companies. It is important for dermatologists to understand the pharmacokinetic properties of SUBA-ITZ vis-a-vis conventional pellet formulation to use it effectively and safely. Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) has established a special interest group for recalcitrant dermatophytosis (SIG-RD) to strengthen research, continuing medical education, and industry collaboration on the subject. This position statement on SUBA-ITZ by SIG-RD is an attempt to address current pieces of evidence and the position of this new formulation in the management of RD., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Dermatology Online Journal.)